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宣布时辰:2020-08-03    文章来历://aqygyl.com/    

体系评价/Meta阐发指周全搜集一切相干研讨并逐一停止严酷评价和阐发,阐发再用定性或定量分解的注册体例对材料停止处置得出综合论断的研讨体例。在指点学生的具体进程中发明初学者在进修进程中经常会碰着良多个性标题标题题目,本公家号特此开设专栏解答,步骤但愿能够或许或许和大师配合进修交换Meta阐发,示例配合生长,阐发若有不妥的地方,注册还请大师攻讦斧正。具体本期咱们将侧重先容Meta阐发的步骤注册流程。

01

叙言


后期咱们向大师具体解读了Meta阐发须要注册的示例缘由:【Meta阐发】Meta阐发该不该注册?若何注册?甚么时辰注册?,可是阐发在理论进程中发明良多学生依然对PROSPERO注册平台和注册条款不熟习,填写存在必然坚苦,注册因此本期专栏咱们将以实例演示,具体具体先容注册的步骤步骤,希冀赞助大师走好Meta阐发万里长征第一步。示例

02

注册账号


对第一次利用PROSPERO的用户,须要实现账号注册,进入/prospero/,点击右上方的Join,实现姓名、通信地点、邮箱、暗码、手机号码、单元机构、国度、身份信息、体系评价的标的目标、小我的研讨标的目标等,这局部内容比拟简单,咱们不再胪陈,可是填写时务必当真看待,由于这些信息将作为注册时你的小我信息记实在研讨打算中。

03

注册步骤

在Meta阐发步骤前,小我须要肯定Meta阐发是不是合适注册请求(普通来讲在数据提取之前),研讨打算靠近终究状况不会有较大的点窜,团队其余成员不反复注册和该注册标题标题题目与数据库现有名目不反复(可经由过程search功效查找关头词检索),知足这些前提后再去挑选注册植物的体系评价仍是人体实验的体系评价,凡是咱们人体临床实验停止注册。
在挑选后凡是咱们须要回覆几个标题标题题目能力停止下一个步骤,这几个标题标题题目肆意回覆毛病都能够或许形成注册步骤没法持续,因此大师须要当真填写(即便挑选毛病也有机遇能够或许变动)。
特别须要注重的是在最初的Stage of review,今朝信息提取前都能够或许停止注册,因此前三项的挑选对注册不影响,但Data extraction必须挑选Not started,不然没法实现注册,同时由于偏倚危险评价和数据阐发是在信息提取以后停止的,从时辰逻辑下去讲也必须挑选Not started,即便你挑选其余项也会进入注册流程,可是不合适规范的有能够或许会被退回。
固然网站撑持在线填写,可是激烈倡议大师在注册前在Word中将所需名目均填写实现再复制到网站停止注册,这也是Have you written a protocol?挑选是和否都能够或许的缘由。

04

注册实例


填写实现后点击register your review便可进入注册页面填写研讨打算,首要信息以下(咱们将连系PRISMA报告规范停止实例解读,此中*代表必填项):
1. Review Title(*): 以PICOS构建标题标题题目,同时连系PRISMA报告规范,需标明meta-analysis/systematic review等信息
比方:
  1. A systematic review and meta-analysis of rehabilitation in patients with sepsis(表现PI)
  1. A network meta-analysis of interventions to control myopia progression in children(表现PO)
  2. Minocycline in depressive symptoms: a meta-analysis of randomized controlled trials(表现PIS)
2. Original language title: 原始标题标题题目,若体系评价不是打算用英文撰写,应在此名目下用撰写体系评价的说话填写标题标题题目
3. Anticipated or actual start date(*) 预期/现实起头时辰
4. Anticipated completion date (*) 预期实现时辰
5. Stage of review at time of this submission (*) 注册时该研讨实现的进度(首要便是咱们方才停止的挑选,不能停止变动,因此在挑选时牢记挑选数据提取之前
6. Named contact (*)   通信作者姓名
7.Named contact E-mail(*)  通信邮箱
8. Named contact address  接洽地点
9.Named contact number  接洽德律风
10.Organizational affiliation of the review(*)体系评价展开的单元
此中6-10项为账号注册时的信息,若现实环境不是通信作者的邮箱停止注册的,则能够或许在这一步停止批改 
11. Review team members and their organizational affiliations(*)  评价小组成员和各自的单元
12. Funding sources/Sponsors(*)  帮助来历
无资金帮助不影响注册是不是胜利 
13.Conflicts of interests(*)  有不好处抵触
14.Collaborators 协作者
15. Review question(*) 体系评价拟处理的标题标题题目,限定250词。
凡是标明该研讨的目标,能够或许因此问句或陈说句的情势,比方
  1. 干涉干与性meta阐发:The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of adjunctive minocycline for depressive symptoms regardless of the main psychiatric condition.
  2. Whether could IgA nephropathy patients benefit from omega-3 fatty acids treatment? How do the kidney function and daily proteinuria of IgA nephropathy patients change after taking omega-3 fatty acids comparing with placebos?
  3. 率的meta阐发:What is the prevalence of neuropathic pain in patients with symptomatic knee osteoarthritis?
也能够或许自问自答:What are the effects of the various optical, pharmacological and lifestyle interventions in preventing myopia progression in children? We aim to generate a clinically useful summary of the interventions based on their efficacy.
16.Searches(*)   申明检索体例和检索数据库,申明检索日期和检索限定
这局部内容中不须要给出完美的检索战略(可作为附件上传),首要描写检索的体例和检索词的关头词,比方:
  1. We will search, with no time restrictions, the following databases for relevant English language literature: PubMed (MEDLINE), the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science.The search string will be built as follows: 可替代(Osteoarthritis OR OA) AND (pain) AND (neuropathic OR nociceptive OR central sensitization OR DN4 OR painDETECT OR S-LANSS OR quantitative sensory testing). The electronic database search will be supplemented by a manual search of the reference lists of included articles.
  2. We will search articles in three electronic database including PubMed, EMBASE and Cochrane Library. All the English publications until 30 April 2018 will be searched without any restriction of countries or article type. Reference list of all selected articles will independently screened to identify additional studies left out in the initial search.
固然有注册胜利的记实间接给出了完全的检索战略,但咱们这里不保举如许做,由于指引已明白指出:
Do NOT enter the full search strategy (it may be provided as a link or attachment.) 
17. URL to search strategy 给出检索战略细节的网址,或你的检索体例的链接
可上传完全检索战略的PDF文档,上传后则默许能够或许公然拜候,清算的格局以不#1、#2、#3的情势,具体能够或许参与课程。
18. Condition or domain being studied(*) 对研讨的疾病,安康终局或卫生范畴停止扼要申明,限200字
 相称因而论文背景局部的简化版,普通包含疾病的概述和风行病学数据、干涉干与办法的研讨近况与缺乏等信息
如:
  1. Supracondylar humeral fracture(SCHF) is the extremely common pediatric fracture in children younger than 15 years, accounting for approximately 75% of all pediatric elbow injuries. It has been suggested that 96% of all SCHFs are extension-type injuries that occur during falls onto the outstretched hand, whereas between 1% and 2% occur through falls onto the olecranon with the elbow flexed. Supracondylar fractures, most commonly, are classified according to Gartland ’s criteria: types I (nondisplaced and stable), type II (hinged fractures with the posterior cortex intact), and type III (completely displaced).
  2. Depression in adults, and its treatment using cognitive remediation therapy.Cognitive remediation therapy is the general term for a kind of psychotherapy which focuses on correcting and changing patients' adaptations to benign cognition. Its main goal is the remediation of bad cognition, but the patient's emotions and the behavior can also be changed.
19. Participants/population(*) 给出明白的体系评价的研讨工具的归入和解除规范
首要描写P,如Adults with depression (as diagnosed by a clinician, or using any recognized diagnostic criteria) will be included. 
但在这里须要指出的是解除规范必然是在归入规范的规模外面再停止解除,不能呈现下述抒发如归入小于18岁,解除18岁以上(即便注册胜利也毛病多多,首要缘由是不规范的把握体例学)
20. Interventions /exposure(*) 给出清楚的体系评价中的干涉干与和裸露的界说
这一局部首要描写I,可简单也可庞杂,可是尽能够能够或许或许切近成稿论文
Physical exercise was the main intervention (e.g. aerobic exercise, resistance exercise and multicomponent exercise program).
21. Comparators/control(*) 具体申明将与检查的主题停止比拟的备选计划(如一项干涉干与或非裸露对比组)。
绝对干涉干与办法,首要描写对比办法
22. Types of study to be included (*) 归入的研讨范例
普通环境下咱们归入随机对比实验,则能够或许表述为Randomized controlled trials (RCTs) will be included.这一局部也能够或许对颁发时辰、说话范例等做限定如Randomized clinical trials will be included irrespective of blinding, publication status or language.,但不倡议对P或I做更多的描写
23. Context 对有助于归入和解除规范的特点信息停止论述,可不填
24. Main outcomes(*) 体系评价的首要终局
简单写一下称号,如overall survival (OS) and progression-free survival (PFS).或某个量表的变更如mean change in WOMAC pain,须要连系本身的研讨停止判定
     Measures of effect(*) 终局目标的效应量
描写终局目标的效应量,如二分类变量挑选RR/OR, 持续性变量挑选SMD/MD, 保存阐发材料选HR
25. Additional outcomes(*) 研讨相干的其余成果
与首要终局目标体例不异,首要填写体系评价的主要终局目标
26. Data extraction (*)  挑选研讨和归入研讨的数据材料的提取
普通有模版,先表现两人自力提取,第三人处理不合如Two authors will independently extract data. Any disagreement will be resolved by discussion until consensus is reached or by consulting a third author.同时最好加上须要提取哪些信息,如The following data will be extracted: author, year of publication, country where the study was conducted, study period, original inclusion criteria, total number of people included in the study, doses of progesterone and time of application, and mean cervical length.
27. Risk of bias(quality) assessment (*)   对体系评价能够或许存在的偏倚危险停止评价